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Diphenhydramine is a common ingredient in sleeping aids; it is also used to treat allergies. While effective, the risk of serious diphenhydramine side effects including confusion, dizziness, urinary retention, and liver or kidney issues is increased in people age 65 and older. How Does Benadryl Work? Diphenhydramine affects the body’s organs, especially the liver, and it can cause permanent damage to the kidneys Histamine is an important mediator of immediate hypersensitivity reactions acting locally and causing smooth muscle contraction, vasodilation, increased vascular permeability, edema and inflammation. Histamine acts through specific cellular receptors which have been categorized into four types, H1 through H4. Antihistamines represent a class of medications that block the histamine type 1 (H1 drotader mf uses Benadryl isn t known to cause liver damage. But it s often combined with other medications, such as acetaminophen (Tylenol), that can. So it s best to always follow the package instructions and not to take more medication than recommended. At recommended doses, Benadryl shouldn t harm the heart. Prerenal Injury. Prerenal injury (i.e, decreased blood flow to the kidney) is defined as hypoperfusion with or without arterial hypotension. Depletion in intravascular volume caused by hemorrhage, excessive gastrointestinal (GI) losses, dehydration, or diuretic therapy can result in hypoperfusion via systemic arterial hypotension. 7

Benadryl (diphenhydramine); Claritin (loratadine) or Claritin-D liver damage. Combining these drugs with alcohol can make the risks As both Diphenhydramine and Ethanol produce somnolence, fatigue, dizziness, and affect the person’s ability to concentrate, it is abundantly